Experimental Studies of Molybdenum Physiology and Toxicity
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- Category: Molybdenum knowledge
- Published on 09 September 2013
- Written by 陈桂兰
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Toxicity studies of molybdenum trioxide, ammonium and calcium molybdates and molybdenum disulfide were carried out with rats and guinea pigs by the U.S. Public Health Service Molybdenum trioxide and the molybdates when fed in large daily doses of from 1200 to 6000 mg Mo/kg body weight invariably proved fatal. Fatalities were few at doses of 120 to 600 mg. There were no fatalities with molybdenum disulfide. The highest dose corresponds to 420g for a 70 kg human being. In inhalation experiments (5 mg Mo/cu. ft. air) molybdenum trioxide and ammonium dimolybdate were injurious but molybdenum disulfide was much less so. Fumes of molybdenum trioxide produced by arcing across molybdenum electrodes were less toxic than molybdenum trioxide powder apparently because the rate of solution of the fume is greater on account of its small particle size (1.55 um) than that of the powder (15.6 um). So the fume is rapidly dissolved in the lungs and carried away from the site of deposition. Molybdenum trioxide and the molybdates also produced toxic effects when administered orally and by intraperitoneal injection in large doses (400 to 800 mg/kg).
In a series of tests with rats and rabbits it was found that calcium, strontium, and zinc molybdates were nontoxic with respect to oral administration, skin absorption and skin irritation, and except for calcium molybdate, eye irritation . Ammonium molybdate was toxic by oral administration and was also an eye irritant.
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