Activity Changes of Molybdenum Hydroxylases in Liver
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- Category: Molybdenum knowledge
- Published on 01 August 2013
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The aim of this study is to investigate the effect of diabetes induction on the specific activity of two molybdenum hydroxylases, namely aldehyde oxidase and xanthine oxidase.
Streptozotocin in a single i.p. injection (65 mg/kg) induced diabetes in male Wistar rats as indicated by a sharp and significant increase of plasma glucose level after 5 days of the treatment.
Three tissues (liver, kidney and jejunum) were excised and assayed for the activity of aldehyde oxidase and xanthine oxidase.
Two substrates (phthalazine and 3-methylisoquinoline) were used to measure aldehyde oxidase activity, while xanthine was used for xanthine oxidase.
Hepatic aldehyde oxidase activity was increased significantly (P < 0.025) in diabetic rats as compared to controls when phthalazine was used as a substrate.
The other two tissues (kidney, jejunum) did not show any significant variation in aldehyde oxidase activity when diabetic and control rats were compared.
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