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Molybdenum and Diabetes，2013 - I

Molybdenum can Lower blood glucose and free fatty acid levels.Both Na2MoO4 (used as a control) and cis-MoO2L22 L= maltol (3-hydroxy-2-methyl-4-pyrone) were effective in lowering blood glucose and free fatty acid levels. Diabetic rats treated with molybdate showed significant improvements in postischemic cardiac function.

A study of molybdenum (VI) compounds as potential anti-diabetic agents is reported. Oxo anions ([MO4]2/3−, where M = V, Cr, Mo or W) have anti-diabetic properties. It is considered that oxoanions inhibit the tyrosine phosphatase enzyme by replacing phosphate in the active centers of the enzyme thereby enhancing insulin signalling.

In the body oxoanions are not absorbed via the intestine. Therefore the idea is to supply molybdenum as an uncharged hydrophobic complex capable of being absorbed in the intestine and converted in the blood stream to molybdate. The complexes should be stable under gastric and intestinal digestion conditions. The study also, incidentally, provides information on the stability and speciation of molybdenum compounds and molybdate under digestive conditions and in the blood.

The compounds studied were sodium molybdate and complexes [MoO2L2] where L is a bidentate ligand:
A: sodium molybdate, Na2[MoO4]

B: [MoO2(acac)2] (B; acacH = acetylacetone = 2,4-pentanedione) having molybdenum (VI) in distorted octahedral coordination by six oxygens

C: [MoO2(cyset)2] (C;cysetH = L-cysteine ethyl ester) having molybdenum (VI) in distorted octahedral coordination by two oxygens, two nitrogens and two sulfurs

D: [MoO2(dedtc)2](D; dedtcH = N,N-diethyldithiocarbamic acid). having molybdenum (VI) in distorted octahedral coordination by two oxygens and four sulfurs

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