Molybdenum Anti-tumour Compounds
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- Category: Molybdenum knowledge
- Published on 29 March 2013
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Molybdenum is an essential trace element and is a component of vitamin and mineral supplements. Some therapeutic uses of molybdenum compounds are described in this section.
Five molybdenum-containing polyoxometalate (POM) bisphosphonate complexes have been synthesised and characterized with alendronic acid ((H2O3P)C(C3H6NH2)(OH)PO3H2 . They are water soluble. Their activities against three human tumor cell lines were investigated in vitro.
The compound Na2Rb6[((Mo3O8)-O-VI)4(O3PC(C3H6NH3)(O)PO3)4]. 26H2O (a fully oxidized (molybdenum(VI) dodecanuclear POM) has IC50 values of about 10 mu m, which is about four times the activity of the parent alendronate molecule on a per-alendronate basis, which opens up the possibility of developing novel drug leads based on molybdenum bisphosphonate clusters.
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