The Release From Cobalt–Chromium–Molybdenum Alloys, 2013-II

Chromium release from the 2 materials was also very low (0.06–0.38 μg/cm2/2 days from stainless steel and 0.52–1.36 μg/cm2/2 days from cobalt–chromium–molybdenum alloy ). In contrast, AS led to abundant cobalt release (maximally 18.94 μg/cm2/2 days) from the CoCrMo discs.

With concomitant eczematous reaction upon patch testing: 0 of the 52 metal-allergic patients reacted to stainless steel discs and 5 of the 52 patients to CoCrMo discs (all 5 patients were cobalt allergic and 3 also nickel and chromium allergic).

None of the controls reacted to the discs. Apart from nickel being a focus of allergological research, our results point to the possibly underestimated association of cobalt release and potential hyperreactivity to cobalt–chromium–molybdenum alloy.
 

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