Molybdenum and Diabetes，2013 - III
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- Category: Molybdenum knowledge
- Published on 29 March 2013
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Combination of molybdate with the medicinal plant Teucrium polium L. can improve islet cells function before transplantation.Islet transplantation has become a promising treatment in the therapy of type 1 diabetes. Its function improvement, after isolation and before transplantation, is crucial because of the loss in number and function of islets after isolation. Sodium orthovanadate and sodium molybdate and the medicinal plant Teucrium polium L. possess high beneficial antioxidative potential and hypoglycemic properties via their effect on islets.
Their effect on cultured islet function was evaluated. Rat pancreatic islets were cultured for 24 h then incubated with different concentrations of Teucrium polium L. (0.01 and 0.1 mg/mL) alone and in combination with sodium orthovanadate (1 mM) or sodium molybdate (1 mM). Insulin concentration in buffer media was measured as islet secretory function.
Administration of Teucrium polium L. (0.01 mg/mL), sodium molybdate, and sodium orthovanadate alone or in combination with each other increased insulin secretion at high glucose concentration (16.7 mM); insulin secretion was greater in the group containing both Teucrium polium L. and sodium molybdate than other treated groups (p < 0.05).
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