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The influence of molybdenum on the copper metabolism of the rat at different copper levels of the diet.

1.Male WAG/Cpb inbred rats fed on rations with approximately 1-5 rng copper/kg (deficient), 6.0 mg copper/kg (adequate) and 25.0mg copper/kg (excess) are supplemented with varying amounts of molybdenum (0, 50, 150 and 500 mg/kg diet) (as ammonium heptamolybdate) and the effect on the copper concentration of blood, plasma, liver and kidney,the caeruloplasmin activity of plasma and the molybdenum concentration of liver and kidney are studied. Copper is supplied as copper(II) nitrate
.
2. Molybdenum increases the copper concentration of blood, plasma, liver and kidney and the molybdenum concentration of liver and kidney.

3. In the plasma of molybdenum-supplemented rats the presence of a copper-containing fraction is demonstrated, the copper of which did not react with dithiocarbamate and was not related to caeruloplasmin. The copper in this

Fraction is not able to increase the caeruloplasmin activity in the plasma of copper-deficient molybdenum-supplemented rats. The copper concentration of the erythrocytes does not seem to have been increased by the molybdenum treatment.

4.When compared to copper-adequate rats the effect of molybdenum on the copper distribution is reduced both by copper deficiency and copper excess. This decreased effect of molybdenum is explained by reduced uptake or retention of molybdenum in the body as observed in the liver and kidney.

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